64 research outputs found
Immersive Experience: Evoking the Elements of Contemplative Space in Japanese Architecture
This research project investigates the creation of
immersive contemplative viewing experiences within my visual arts
practice by identifying and adapting the fundamental elements of
Japanese contemplative space into my aesthetic and conceptual
lexicon. Contemplative experience is an intrinsic aspect of the
human experience which has become increasingly scarce in this age
of perpetual overstimulation and increasing secularisation. The
primary goal of the research project is to provide a significant
opportunity for new audiences to engage in meaningful
contemplative experience informed by the centuries-old principles
of yūgen 幽玄, ma 間, and hikari to kage 光と影 within
Japanese architecture. The studio-based research first explores
the creation of contemplative objects constructed with glass,
followed by a series of maquettes of potential immersive
contemplative environments. The research culminates with the
immersive installation, Lux Mandala, which utilises the material
characteristics of glass microspheres to synthesise the ephemeral
optical phenomenon of the “glory” into a meditative encounter
with light, shadow, space, transience and profundity. By
aesthetically locating the viewer at the centre of this
phenomenon, the viewer’s presence and perceptual mechanisms
complete a participatory loop, allowing the phenomenon to enter
into existence while enabling the viewer to reflect upon its
nature, notions of perception and transience, and the
significance of their own presence within this evanescent
tableau. The outcomes of this research project represent a
significant new nexus between visual arts practice, immersive
experience, and the essence of Japanese contemplative space
Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
Inflammatory arthritis is associated with the release of a network of key cytokines. In T cell receptor transgenic K/BxN mice interleukin (IL)-1 plays a key role in joint swelling and destruction, as suggested by the ability of anti–IL-1receptor (IL-1R) antibody treatment to delay the onset and slow the progression of this disease. This mechanism is dependent on the signaling pathway intermediary myeloid differentiation factor 88 (MyD88), such that neither IL-1R nor MyD88-deficient mice developed visually detectable synovitis after transfer of arthritogenic sera. The Toll-like receptors (TLRs) share the same signaling pathway through MyD88 as the IL-1R. The administration of a TLR-4 ligand, lipopolysaccharide, concomitant with arthritogenic serum in IL-1 receptor–deficient mice resulted in acute paw swelling, but not in MyD88-deficient mice. Also, serum transferred arthritis was not sustained in TLR-4 mutant mice compared with controls. These results suggest that innate immune functions via TLR-4 might perpetuate inflammatory mechanisms and bypass the need for IL-1 in chronic joint inflammation
Impact of increased penetration of low-carbon technologies on cable lifetime estimations
Cables are the largest assets by volume on power distribution networks and the assets with the least health information routinely gathered. Projections over the next 8 years suggest increased penetration of low-carbon technology (LCT) at the distribution level with higher loads resulting from electric vehicle (EV) and heat pump uptake. Over this period, increased cable loading will directly influence their lifetimes and may mean that existing asset management practices need to be revised to understand the specific impact on end-of-life assessment. Accordingly, this paper uses a physics-based thermal lifetime model based on projected uptake trends for LCTs to evaluate the impact on distribution cable lifetime. Two case studies are presented considering portions of network and the ultimate impact on asset life over the next decade. Two commonly used cables are considered to quantify the lifetime reduction caused by LCT for asset fleets. The paper shows that the projected uptake of EVs and heat pumps will have a detrimental effect on cable life with a 30% reduction in cable lifetime possible
Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand
Although the mechanisms for sustained chemokine gradients and recurring cell infiltration in sterile peritonitis have not been elucidated, toll-like receptors (TLRs) have been implicated. To abate the deleterious recruitment of neutrophils in sterile inflammation, we repeatedly administered a TLR7 ligand that hyposensitized to TLR7 and receptors that converged on the MyD88-signaling intermediary and reduced cellular infiltration in murine autoimmune models of multiple sclerosis and arthritis. To reduce potential adverse effects, a polyethylene glycol polymer was covalently attached to the parent compound (Tolerimod1). The proinflammatory potency of Tolerimod1 was 10-fold less than the unconjugated TLR7 ligand, and Tolerimod1 reduced neutrophil recruitment in chemically induced peritonitis and colitis. The effects of Tolerimod1 were mediated by the radioresistant cells in radiation chimeric mice and by mast cells in reconstituted mast cell-deficient mice (KitW-sh). Although the Tolerimod1 had weak proinflammatory agonist activity, it effectively reduced neutrophil recruitment in sterile peritoneal inflammation
Characteristics of In Situ Fine Fraction Aerosol Spectra from 300-700 nm Observed Around the Korean Peninsula During KORUS-OC
In situ aerosol extinction and absorption spectra covering the 300-700 nm range at 1 nm spectral resolution were measured aboard the R/V Onnuri during the Korea U.S. Ocean Color (KORUS-OC) cruise around the Korean Peninsula from May 21 through June 3, 2016. Total absorption spectra were obtained from aerosols collected on glass fiber filters and subsequently placed in the center of an integrating sphere (Labsphere DRA-CA-30) attached to a dual beam spectrophotometer (Cary 100 Bio UV-Visible Spectrophotometer, 0.2 nm spectral resolution). Absorption spectra from methanol and deionized water extracts of aerosols collected on Teflon filters were measured in a liquid waveguide capillary cell (World Precision Instruments LWCC- 3100, ~0.4 nm spectral resolution). Extinction spectra were measured with a custom built instrument (SpEx, ~0.8 nm spectral resolution). The measurements were obtained at a height of ~10 m above the sea surface with an inlet that limited the measured aerosols to diameters 1.3 m. All four sets of spectra exhibit curvature in log-log space with 2nd order polynomials providing a better fit to the measured spectra than power law fits. The deionized water extracts were also analyzed with an ion chromatograph (Dionex ICS-3000 Ion Chromatography System) and with an aerosol mass spectrometer (Aerodyne Research, Inc. HR-ToF High Resolution Aerosol Mass Spectrometer) to examine chemical composition. These data indicate the optical spectra are sensitive to differing chemical properties of the measured ambient aerosols and suggest differing sources and/or atmospheric processes influence the observed optical signatures. The measured suite of spectra are combined to examine the spectral characteristics of single scattering albedo, as well as to examine the contribution of soluble absorbing chromophores to the total absorption spectra. Additional measurements made during the affiliated Korea U.S. - Air Quality (KORUS-AQ) campaign will be used to provide further insight on the observed spectral characteristics
Biofuel Blending Reduces Aircraft Engine Particle Emissions at Cruise Conditions
Aviation aerosol emissions have a disproportionately large climatic impact because they are emitted high in the relatively pristine upper troposphere where they can form linear contrails and influence cirrus clouds. Research aircraft from NASA, DLR, and NRC Canada made airborne measurements of gaseous and aerosol composition and contrail microphysical properties behind the NASA DC-8 aircraft at cruise altitudes. The DC-8 CFM-56-2C engines burned traditional medium-sulfur Jet A fuel as well as a low-sulfur Jet A fuel and a 50:50 biofuel blend. Substantial, two-to-three-fold emissions reductions are found for both particle number and mass emissions across the range of cruise thrust operating conditions. These observations provide direct and compelling evidence for the beneficial impacts of biojet fuel blending under real-world conditions
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